Targeting transcription and chromatin deregulation in cancer.
MYC in cancer
Understanding how this devastating oncogenic transcription factor reshapes tumor gene expression programs
See Lin et al., Cell 2012, Wolf et al., TICB 2014, and Zeid et al., Nat. Genetics 2018
Therapeutics of Gene control
We are excited to be part of the new Therapeutic Innovation Center at BCM to drive experimental therapeutics in diseases of altered gene regulation.
Computational Biology
Modeling of transcription factor networks and enhancer regulation in cancer and cardiovascular disease
Chemical Biology
Using selective inhibitors of transcription and chromatin to modulate cell state
See Loven et al., Cell 2013, Anand et al., Cell 2013, Brown et al., Mol. Cell 2014, and Shu et al., Nature 2016
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RT @JonathanBrownMD: Congrats to Ronan Bracken graduate student in @JonBrownLab. Advancing to PhD candidacy in @VandyBiochem. #donewithquals!!! 🙌🧬🧬🧬 -
We're hiring! Looking for someone who is passionate about all things -seq and is hand-on tinkerer. Come drug transc… https://t.co/wxDoHBCvUw
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RT @BrunettiLab: Check out our latest review on NPM1-mutated AML just published in @BloodJournal. From the cover: IHC demonstrating… https://t.co/2KhUvSSXdm
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Taking a page from @Goodell_Lab Peggy’s ISSCR talk! DIY recording studios! https://t.co/r0smvVuvYb https://t.co/2afCVPMyyY
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RT @Michael_A_Erb: Super bummed to learn a post-doc will no longer come due to developing fears of US immigration. Please help us get… https://t.co/NywPsKpypk
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Didn't see this till now. Toddler's first tweet on my phone. Sharing our love of Monster Jam aka truck dressage https://t.co/93td1AByNO
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Monster Jam 2019: Miami, Florida (FULL SHOW) | Motorsports on NBC https://t.co/hTm9QEAade via @YouTubeweeeeettrTgjj… https://t.co/PPeZQgkKCe
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Didn't get a chance to properly celebrate with all the craziness around, but congrats to Ken Eagle and… https://t.co/UETGkegxy5
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Lin lab virtual lab meeting! Great to see everyone! Dan, please go outside and get some vitamin D and exercise! https://t.co/ivtdOjBUPN
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RT @ScacheriLab: Big congrats to freshly minted PhD, Andrew Morton. He just successfully defended his thesis online! @morton_andrew #DamnProud
